The Center for Biomolecular NMR Spectroscopy offers state-of-the-art high field NMR instrumentation for structural studies of biological macromolecules. The instrumentation presently available includes four-channel Bruker Avance 500, 600, and 700 MHz NMR spectrometers. The facility also has available an ultrahigh sensitivity 5mm ¹H-¹³C-¹⁵N triple-resonance cold probe for the 600 MHz spectrometer. The resources of the facility can be accessed either on a fee-for-service or on a collaborative use basis. The types of analyses conducted on a fee-for-service basis include acquisition and analysis of the required spectra for elucidation of small molecule structures (includes synthetic molecules, natural products, cofactors, lipids, and short peptides (30 amino acids or less)). The types of projects conducted collaboratively include the determination of three-dimensional structures of biological macromolecules, including proteins and nucleic acids, both alone and as complexes with various ligands. The instrumentation available in the Center was purchased through funds provided by the NIH National Center for Research Resources, the Houston Endowment, the UTHSCSA Children's Cancer Research Center, and the U. Texas Permanant University Fund (see Facility History). The operational costs of the facility are supported by the Macromolecular Shared Resource of the San Antonio Cancer Institute, the UTHSCSA Core Facilities Committee, and User Fees.

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