Peer-Reviewed Articles:

Migita, C.T., Salerno, J.C., MASTERS, B.S.S., Martásek, P., McMillan, K., and Ikeda-Saito, M. (1997) Biochemistry, 36, 10987-10992. "Substrate Binding-Induced Changes in the EPR Spectra of the Ferrous Nitric Oxide Complexes of Neuronal Nitric Oxide Synthase."

Wang, M., Roberts, D.L., Paschke, R., Shea, T.M., MASTERS, B.S.S., and Kim, J.-J. P. (1997) Proc. Natl. Acad. Sci., USA, 94, 8411-8416. "Three-dimensional Structure of NADPH-cytochrome P450 Reductase: Prototype for FMN- and FAD-containing Enzymes."

Vásquez-Vivar, J., Martásek, P., Hogg, N., MASTERS, B.S.S., Pritchard, K.A., and Kalyanaraman, B. (1997) Biochemistry, 36, 11293-11297. "Endothelial Nitric Oxide Synthase-dependent Superoxide Generation from Adriamycin."

Miller, R.T., Martásek, P., Roman, L.J., Nishimura, J.S., and MASTERS, B.S.S. (1997) Biochemistry, 36, 15277-15284. "Involvement of the Reductase Domain of Neuronal Nitric Oxide Synthase in Superoxide Anion Production."

García-Cardeña, G., Martásek, P., MASTERS, B.S.S., Skidd, P.M., Couet, J., Li, S., Lisanti, M.P. and Sessa, W.C. (1997) J. Biol. Chem., 272,25437-25440. "Dissecting the Interaction Between Nitric Oxide Synthase (NOS) and Caveolin."

Salerno, J.C., Harris, D.E., Irizary, K., Patel, B., Morales, A.J., Smith, S.M.E., Martásek, P., Roman, L.J., MASTERS, B.S.S., Jones, C.L., Weissman, B.A., Lane, P., Liu, Q., and Gross, S.S. (1997) J. Biol. Chem., 272, 29769-29777. "An Autoinhibitory Control Element Defines Calcium-Regulated Isoforms of Nitric Oxide Synthase."

Tierney, D.L., Martásek, P., Doan, P.E., MASTERS, B.S.S., and Hoffman, B.M. (1998) J. Am. Chem. Soc., 120, 2983-2984. "Location of Guanidino N of L-Arginine Substrate Bound to nNOS: Determination by Q-band Pulsed ENDOR spectrospcopy."

Martásek, P., Miller, R.T., Liu, Q., Roman, L.J., Salerno, J.C., Migita, C.T., Gross, S.S., Ikeda-Saito, M., MASTERS, B.S.S. (1998) J. Biol. Chem., 273, 34799-34805. "The Cys331Ala Mutant of Neuronal Nitric Oxide Synthase is Defective in Arginine Binding."

Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg., N., MASTERS, B.S.S., Karovi, H., Tordo, P., and Pritchard, K.A. (1998) Proc. Natl. Acad. Sci. USA, 95, 9220-9225. "Superoxide Generation by Endothelial Nitric Oxide Synthase: The Influence of Cofactors."

Xia, Y., Roman, L.J., MASTERS, B.S.S., and Zweier, J.L. (1998) J. Biol. Chem., 273, 22635-22639. "Inducible Nitric Oxide Synthase Generates Superoxide from the Reductase Domain."

Lee, Y., Marletta, M.A., Martásek, P., Roman, L.J., MASTERS, B.S.S. and Silverman, R.B. (1998) Bioorg. Med. Chem., 7, 1097-1104. "Conformationally-Restricted Arginine Analogues as Alternative Substrates and Inhibitors of Nitric Oxide Synthases."

Raman, C.S., Li, H., Martásek, P., Král, V., MASTERS, B.S.S., and Poulos, T.L. (1998) Cell, 95, 939-950. "Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase: A Paradigm for Pterin Function Involving a Novel Metal Center."

Hosny, G., Roman, L.J., Mostafa, M.H., MASTERS, B.S.S. (1999) Arch. Biochem. Biophys., 366, 199-206. "Characterization of Purified E. coli-expressed Cytochrome P450 4A5."

Nishimura, J.S., Narayanasami, R., Miller, R.T., Roman, L.J., Panda, S., and MASTERS, B.S.S. (1999) J. Biol. Chem., 274, 5399-5406. "Stimulatory Effects of Hofmeister Ions on the Activities of Neuronal Nitric Oxide Synthase. Apparent Substrate Inhibition by L-Arginine is Overcome in the Presence of Protein Destabilizing Agents."

Miller, R.T., Martásek, P., Raman, C.S., and MASTERS, B.S.S. (1999) J. Biol. Chem., 274, 14537-14540. "Zinc Content of E. coli-Expressed Constitutive Isoforms of Nitric Oxide Synthase: Enzymatic Activity and Effect of Pterin"

Tierney, D.L., Huang, H., Martásek, P., MASTERS, B.S.S., Silverman, R.B., and Hoffman, B.M. (1999) Biochemistry, 38, 3704-3710. "ENDOR Spectroscopic Evidence for the Position and Structure of N^G-Hydroxyl-L-Arginine Bound to Holo-Neuronal Nitric Oxide Synthase."

Scheele, J.S., Bruner, E., Kharitonov, V.G., Martásek, P., Roman, L.J., MASTERS, B.S.S., Sharma, V.J., and Magde, D. (1999) J. Biol. Chem., 274, 13105-13110. "Kinetics of NO Ligation with Nitric-Oxide Synthase by Flash Photolysis and Stopped-Flow Spectrophotometry."

Ledbetter, A.P., McMillan, K., Roman, L.J., MASTERS, B.S.S., Dawson, J.H., and Sono, M. (1999) Biochemistry, 38, 8014-8021. "Low Temperature Stabilization and Spectroscopic Characterization of the Dioxygen Complex of the Ferrous Neuronal Nitric Oxide Synthase Ocygenase Domain."

Huang, H., Martásek, P., Roman, L.J., MASTERS, B.S.S., and Silverman, R.B. (1999) J. Med. Chem., 42, 3147-3153. "N^ω-Nitroarginine-Containing Dipeptide Amides Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase."

Lee, Y., Martásek, P., Roman, L.J., MASTERS, B.S.S. and Silverman, R.B. (1999) Bioorg. Med. Chem., 7, 1941-1951. "Imidazole-Containing Amino Acids as Selective Inhibitors of Nitric Oxide Synthases."

Miller, R.T., Martásek, P., Omura, T., and MASTERS, B.S.S. (1999) Biochem. Biophys. Res. Commun., 265, 184-188. "Rapid Kinetic Studies of Electron Transfer in the Three Isoforms of Nitric Oxide Synthase."

Tierney, D.L., Huang, H., Martásek, P., Roman, L.J., Silverman, R.B., MASTERS, B.S.S. and Hoffman, B.M. (2000) J. Am. Chem. Soc., 122, 5405-5406. "ENDOR Studies of L-Arginine and N^G-Hydroxy-L-Arginine Bound to All Three Holo-Nitric Oxide Synthase Isozymes."

Roman, L.J., Miller, R.T., de la Garza, M.A., Kim, J-J., and MASTERS, B.S.S. (2000) J. Biol. Chem.,275, 21914-21919. "The C-terminus of Mouse Macrophage Inducible Nitric Oxide Synthase Attenuates Electron Flow Through the Flavin Domain."

Li, H., Raman, C.S., Martásek, P., Král, B., MASTERS, B.S.S., and Poulos, T.L. (2000) J. Inorg. Biochem., 81, 133-139. "Mapping the Active Site Polarity in Structures of Endothelial Nitric Oxide Synthase Heme Domain Complexed with Isothioureas."

Roman, L.J., Martásek, P., Miller, R.T., Harris, D.E., de la Garza, M.A., Shea, T.M., Kim, J.-J.P., & MASTERS, B.S.S. (2000) J. Biol. Chem., 275, 29225-29232. "The C-Terminus of Constitutive Nitric Oxide Synthase Controls Electron Flow through the Flavin and Heme Domains and Affects Modulation by Calmodulin."

Loughran, P.A., Roman, L.J., Aitken, A.E., Miller, R.T., and MASTERS, B.S.S. (2000) Biochemistry, 39, 15110-15120 "Identification of Unique Amino Acids That Modulate CYP4A7 Activity."

Loughran, P.A., Roman, L.J., Miller, R.T., and MASTERS, B.S.S. (2001) Arch. Biochem. Biophys.,385, 311-321. "The Kinetic and Spectral Characterization of the E. coli-Expressed Mammalian CYP4A7: Cytochrome b₅ Effects Vary with Substrate."

Scheele, J.S., Bruner, E., Zemojtel, T., Martásek, P., Roman, L.J., MASTERS, B.S.S, Sharma, V.S. and Magde, D., (2001) J. Biol. Chem., 276, 4733-4736. "Kinetics of CO and NO Ligation with the Cys³³¹→Ala Mutant of Neuronal Nitric-Oxide Synthase."

Li, H., Raman, C.S., Martásek, P., MASTERS, B.S.S., and Poulos, T.L. (2001) Biochemistry,40,5399-5406. "Crystallographic Studies on Endothelial Nitric Oxide Synthase Complexed with Nitric Oxide and Mechanism-Based Inhibitors."

McCabe, T.J., Roman, L.J., and MASTERS, B.S.S. (2001) Arch. Biochem. Biophys., 393, 78-86. "Induction of Rabbit Lung CYP4A4 Prostaglandin w-Hydroxylase by Various Steroid Hormones."

Aitken, A.E., Roman, L.J., Loughran, P.A., de la Garza, M.A., and MASTERS, B.S.S. (2001) Arch. Biochem. Biophys., 393, 329-338. "Expressed CYP4A4 Metabolism of Prostaglandin E₁ and Arachidonic Acid."

Zhang, J., Martásek, P., Paschke, R., Shea, T., MASTERS, B.S.S., and Kim, J-J.P. (2001) J. Biol. Chem., 276,37506-37513 "Crystal Structure of the Stable Flavin Domain of Rat Neuronal Nitric Oxide Synthase."

Kotsonis, P., Frohlich, L.G., Raman, C.S., Li, H., Berg, M., Gerwig, R., Groehn, V., Kang, Y., Al-Masoudi, N., Taghavi-Moghadam, S., Mohr, D., Munch, U., Schnabel, J., Martásek, P., MASTERS, B.S., Strobel, H., Poulos, T., Matter, H., Pfleiderer, W., Schmidt, H.H. (2001) J. Biol. Chem., 276, 49133-49141. "Structural Basis for Pterin Antagonism in Nitric-Oxide Synthase. Development of Novel 4-oxo-pteridine Antagonists of (6R)-5,6,7,8-tetrahydrobiopterin."

Raman, C.S., Li, H., Martásek, P., Babu, B.R., Griffith, O.W., MASTERS, B.S.S. and Poulos, T.L. (2001) J. Biol. Chem., 276, 26486-26491. "Implications for Isoform-Selective Inhibitor Design Derived from the Binding Mode of Bulky Isothioureas to the Heme Domain of Endothelial Nitric Oxide Synthase."

Raman, C.S., Li, H., Martásek, P., Southan, G., MASTERS, B.S.S., and Poulos, T.L., (2001) Biochemistry, 40, 13448-13455. "Crystal Structure of Nitric Oxide Synthase Bound to Nitro Indazole Reveals a Novel Inactivation Mechanism."

Korn, D., Rich, R.R., Garrison, H.H., Golub, S.H., Hendrix, M.J., Heinig, S.J., MASTERS, B.S., and Turman, R.J. (2002) Science, 296, 1401-1402. "The NIH Budget in the 'Postdoubling' Era."

Roman, L.J., Martásek, P., and MASTERS, B.S.S. (2002) in Chemical Reviews, Nitric Oxide Chemistry, American Chemical Society Publications, Columbus, Ohio (Geroge Richter-Addo, Ed.) Vol. 102, pp. 1179-1190. "Intrinsic and Extrinsic Modulation of Nitric Oxide Synthase Activity."

Davydov, R., Martásek, P., Ledbetter-Rogers, A., Sono, M., Larukhin, M., Dawson, J., MASTERS, B.S.S., and Hoffman, B.M. (2002) Biochemistry, 41, 10375-10381. "EPR and ENDOR Characterization of Intermediates in Cryoreduced oxy-Nitric Oxide Synthase Heme Domain with Bound L-Arginine or N^G-Hydroxy-Arginine."

Roman, L.J., McLain, J., and MASTERS, B.S. (2003) J. Biol. Chem., 278, 25700-25707. "Chimeric Enzymes of Cytochrome P450 Oxido-Reductase and Neuronal Nitric Oxide Synthase Reductase Domain Reveal Structural and Functional Differences."

Zemojtel, T., Scheele, J.S., Martásek, P., MASTERS, B.S.S., Sharma, V.S. and Magde, D. (2003) Biochemistry, 42, 6500-6506. "Role of Interdomain Linker Probed by Kinetics of CO Ligation to an Endothelial Nitric Oxide Synthase Mutant Lacking the Calmodulin Binding (Residues 503-517 in Bovine)."

MASTERS, B.S.S. (Chair), Bazer, F.W., Beresford, S.A.A., Dellapenna, D., Etherton, T.D., Garza, C., Goldman, L., Green, S., Gregory, J.F., Hillard, J., McHughen, A.G., Miller, S.A., Taylor, S.L., and Zacharewski, T.  (2004) Safety of Genetically Engineered Foods: Approaches to Assessing Unintended Health Effects, The National Academies Press, Washington, DC.

Kashyap, S.R., Roman, L.J., Lamont, J., MASTERS, B.S.S., Bajaj, M., Suraamornkul, S., Belfort, R., Berria, R., Kellogg Jr., D.L., Liu, Y., and DeFronzo, R.A. (2005) J. Clin. Endocrinol. Metab., 90(2), 1100-1105. Insulin Resistantce Is Associated with Impaired Nitric Oxide Synthase Activity in Skeletal Muscle of Type 2 Diabetic Subjects.

Jáchymová, M., Martásek, P., Panda, S., Roman, L.J., Panda, M., Shea, T.M., Ishimura, Y., Kim, J-J., and MASTERS, B.S.S. (2005) Proc. Natl. Acad. Sci., USA, 102,44,15833-15838.  “Recruitment of Governing Elements for Electron Transfer in the Nitric Oxide Synthase Family.”

Ishimura, Y., Gao, Y., Panda, S.P., Roman, L.J., MASTERS, B.S.S. and Weintraub, S.T. (2005) Biochem. Biophys. Res. Commun., 338, 543-549.  “Detection of Nitrous Oxide in the Neuronal Nitric Oxide Synthase Reaction by Gas Chromatography-Mass Spectrometry.”

Porter, R., Jáchymová, M., Martásek, P., Kalyanaraman, B. and Váaquez-Vivar, J.  (2005) Chem. Res. Toxicol., 18, 834-843.  “Reductive Activation of Cr(Vi) by Nitric Oxide Synthase.”

Panda, S.P., Gao, Y.T., Roman, L.J., Martasek, P., Salerno, J.C. and MASTERS, B.S.S. (2005) J. Biol. Chem., submitted.  “The Role of a Conserved Serine Residue within Hydrogen Bonding Distance of FAD in Redox Properties and the

Modulation of Catalysis by Ca²⁺/Calmodulin of Constitutive Nitric Oxide Synthases.”

Roman, L.J. and MASTERS, B.S.S. (2006) J. Biol. Chem., submitted.  “Electron Transfer by nNOS is Regulated by Concerted Interaction of Calmodulin and Two Instrinsic Regulatory Elements.”

 Invited Articles:

MASTERS, B.S.S., Martásek, P., and Roman, L.J. (1998) in The Pathophysiology & Clinical Applications of Nitric Oxide, Gordon & Breach Publishing Group, London, U.K. (Gabor M. Rubanyi, Ed.) pp.17-38. "Structural Variations on a Theme of Nitric Oxide Production by Three Isoforms of Nitric Oxide Synthase."

Raman, C.S., Martásek, P., and MASTERS, B.S.S. (2000) in The Porphyrin Handbook, Volume 4, Biochemistry and Binding: Activation of Small Molecules, Academic Press, San Diego, CA (K.M. Kadish, K.M. Smith, R. Guilard, Eds.) pp. 293-339. "Structural Themes Determining Function in Nitric Oxide Synthases."

MASTERS, B.S.S. (2000) in Nitric Oxide, Biology and Pathobiology, Academic Press, San Diego, CA (Louis Ignarro, Ed.) pp. 91-104. "Structural Variations to Accommodate Functional Themes of the Isoforms of Nitric Oxide Synthases."

Roman, L.J., Martásek, P., and MASTERS, B.S.S.(2002) in Chemical Reviews, Nitric Oxide Chemistry, American Chemical Society Publications, Columbus, Ohio (George Richter-Addo, Ed.) pp. 1179-1189. "Intrinsic and Extrinsic Modulation of Nitric Oxide Synthase Acitivity."

Masters, B.S.S. (2005) Biochem. Biophys. Res. Commun., 338, 507-519. "The Journey from NADPH-Cytochrome P450 Oxidoreductase to Nitric Oxide Synthases."

Textbook Chapters:

Okita, R.T. and MASTERS, B.S.S. (1992) Textbook of Biochemistry with Clinical Correlations (T.M. Devlin, Editor) 3^rd Edition, Wiley-Liss, Inc., New York. "Biotransformations: The Cytochromes P450". pp. 981-999.

Okita, R.T. and MASTERS, B.S.S. (1997) Textbook of Biochemistry with Clinical Correlations (T.M. Devlin, Editor) 4^th Edition, Wiley-Liss, Inc., New York. "Biotransformations: The cytochromes P450". pp. 981-1000.

Okita, R.T. and MASTERS, B.S.S. (2002) Textbook of Biochemistry with Clinical Correlations (T. M. Devlin, Editor) 5^th Edition, Wiley-Liss, Inc., New York. "The Cytochromes P450 and Nitric Oxide Synthases". pp. 465-492.

Roman, L.J. and MASTERS, B.S.S. (2005) Textbook of Biochemistry with Clinical Correlations (T.M. Devlin, Editor) 6^th Edition, Wiley-Liss, Inc., New York. "The Cytochromes P450 and Nitric Oxide Synthases". pp. 413-442.